Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II
Identifieur interne : 004037 ( Main/Exploration ); précédent : 004036; suivant : 004038Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II
Auteurs : Nicole Le Moual [France] ; Anne-Elie Carsin [Espagne] ; Valérie Siroux [France] ; Katja Radon [Allemagne] ; Dan Norback [Suède] ; Kjell Toren [Suède] ; Mario Olivieri [Italie] ; Isabel Urrutia [Espagne] ; Lucia Cazzoletti [Italie] ; Bénédicte Jacquemin [Espagne, France] ; Geza Benke [Australie] ; Hans Kromhout [Pays-Bas] ; Maria C. Mirabelli [États-Unis] ; Amar J. Mehta [Suisse, États-Unis] ; Vivi Schlünssen [Danemark] ; Torben Sigsgaard [Danemark] ; Paul D. Blanc [États-Unis] ; Manolis Kogevinas [Espagne, Grèce] ; Josep M. Anto ; Jan-Paul ZockSource :
- The European respiratory journal [ 0903-1936 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médecine du travail, Adulte.
English descriptors
- KwdEn :
Abstract
Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS). Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect. Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma. These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma.
Affiliations:
- Allemagne, Australie, Danemark, Espagne, France, Grèce, Italie, Pays-Bas, Suisse, Suède, États-Unis
- Attique (région), Auvergne-Rhône-Alpes, Bavière, Catalogne, District de Haute-Bavière, East Middle Sweden, Rhône-Alpes, Svealand, Utrecht (province), Victoria (État), Île-de-France
- Athènes, Barcelone, Grenoble, Melbourne, Munich, Orsay, Uppsala, Utrecht
- Université Joseph Fourier, Université Paris-Sud, Université d'Uppsala, Université d'Utrecht
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Le document en format XML
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sortKey="Jacquemin, Benedicte" sort="Jacquemin, Benedicte" uniqKey="Jacquemin B" first="Bénédicte" last="Jacquemin">Bénédicte Jacquemin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Hospital del Mar Medical Research Institute (IMIM), Barcelona and CIBER Epidemiologia y Salud Pública (CIBERESP)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Respiratory and Environmental Epidemiology</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Université Paris Sud, UMRS 1018</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>UMRS 1018</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Benke, Geza" sort="Benke, Geza" uniqKey="Benke G" first="Geza" last="Benke">Geza Benke</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Dept of Epidemiology and Preventive Medicine, Monash University</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kromhout, Hans" sort="Kromhout, Hans" uniqKey="Kromhout H" first="Hans" last="Kromhout">Hans Kromhout</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>12 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Mirabelli, Maria C" sort="Mirabelli, Maria C" uniqKey="Mirabelli M" first="Maria C." last="Mirabelli">Maria C. Mirabelli</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Dept of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine</s1><s2>Winston-Salem, NC</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Winston-Salem, NC</wicri:noRegion></affiliation></author><author><name sortKey="Mehta, Amar J" sort="Mehta, Amar J" uniqKey="Mehta A" first="Amar J." last="Mehta">Amar J. Mehta</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Swiss Tropical and Public Health Institute, Basel; School of Medicine, University of Basel</s1><s2>Basel</s2><s3>CHE</s3><sZ>14 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Dept of Environmental Health, Harvard School of Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Schlunssen, Vivi" sort="Schlunssen, Vivi" uniqKey="Schlunssen V" first="Vivi" last="Schlünssen">Vivi Schlünssen</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Section of Environment, Occupation and Health, Dept of Public Health, Aarhus University</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Sigsgaard, Torben" sort="Sigsgaard, Torben" uniqKey="Sigsgaard T" first="Torben" last="Sigsgaard">Torben Sigsgaard</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Section of Environment, Occupation and Health, Dept of Public Health, Aarhus University</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Blanc, Paul D" sort="Blanc, Paul D" uniqKey="Blanc P" first="Paul D." last="Blanc">Paul D. Blanc</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Division of Occupational and Environmental Medicine, Dept of Medicine, University of California</s1><s2>San Francisco, CA</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Francisco, CA</wicri:noRegion></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Centre for Research in Environmental Epidemiology (CREAL)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>18 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Hospital del Mar Medical Research Institute (IMIM)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>18 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>CIBER Epidemiologia y Salud Pública (CIBERESP)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>18 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>National School of Public Health</s1><s2>Athens</s2><s3>GRC</s3><sZ>18 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Anto, Josep M" sort="Anto, Josep M" uniqKey="Anto J" first="Josep M." last="Anto">Josep M. Anto</name></author><author><name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0057429</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0057429 INIST</idno><idno type="RBID">Pascal:14-0057429</idno><idno type="wicri:Area/PascalFrancis/Corpus">000540</idno><idno type="wicri:Area/PascalFrancis/Curation">005918</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000173</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000173</idno><idno type="wicri:doubleKey">0903-1936:2014:Le Moual N:occupational:exposures:and</idno><idno type="wicri:Area/Main/Merge">004097</idno><idno type="wicri:Area/Main/Curation">004037</idno><idno type="wicri:Area/Main/Exploration">004037</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II</title><author><name sortKey="Le Moual, Nicole" sort="Le Moual, Nicole" uniqKey="Le Moual N" first="Nicole" last="Le Moual">Nicole Le Moual</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology, Villejuif and Université Paris Sud, UMRS 1018</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>UMRS 1018</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Carsin, Anne Elie" sort="Carsin, Anne Elie" uniqKey="Carsin A" first="Anne-Elie" last="Carsin">Anne-Elie Carsin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Hospital del Mar Medical Research Institute (IMIM), Barcelona and CIBER Epidemiologia y Salud Pública (CIBERESP)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Inserm, U823, Centre for Research Albert Bonniot, Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble and Université Joseph Fourier</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Radon, Katja" sort="Radon, Katja" uniqKey="Radon K" first="Katja" last="Radon">Katja Radon</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute for Occupational, Social and Environmental Medicine, Hospital of the Ludwig-Maximilian, University Munich</s1><s2>Munich</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Norback, Dan" sort="Norback, Dan" uniqKey="Norback D" first="Dan" last="Norback">Dan Norback</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Dept of Medical Sciences, Uppsala University</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName><orgName type="university">Université d'Uppsala</orgName></affiliation></author><author><name sortKey="Toren, Kjell" sort="Toren, Kjell" uniqKey="Toren K" first="Kjell" last="Toren">Kjell Toren</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Section of Occupational and Environmental Medicine, Sahlgrenska Academy at University of Gothenburg</s1><s2>Gothenburg</s2><s3>SWE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Olivieri, Mario" sort="Olivieri, Mario" uniqKey="Olivieri M" first="Mario" last="Olivieri">Mario Olivieri</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Unit of Occupational Medicine, University of Verona</s1><s2>Verona</s2><s3>ITA</s3><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Urrutia, Isabel" sort="Urrutia, Isabel" uniqKey="Urrutia I" first="Isabel" last="Urrutia">Isabel Urrutia</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Respiratory Dept, Galdakao Hospital</s1><s2>Galdakao</s2><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Galdakao</wicri:noRegion></affiliation></author><author><name sortKey="Cazzoletti, Lucia" sort="Cazzoletti, Lucia" uniqKey="Cazzoletti L" first="Lucia" last="Cazzoletti">Lucia Cazzoletti</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Unit of Epidemiology and Medical Statistics, Dept of Medicine and Public Health, University of Verona</s1><s2>Verona</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Jacquemin, Benedicte" sort="Jacquemin, Benedicte" uniqKey="Jacquemin B" first="Bénédicte" last="Jacquemin">Bénédicte Jacquemin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Hospital del Mar Medical Research Institute (IMIM), Barcelona and CIBER Epidemiologia y Salud Pública (CIBERESP)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Respiratory and Environmental Epidemiology</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Université Paris Sud, UMRS 1018</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>UMRS 1018</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Benke, Geza" sort="Benke, Geza" uniqKey="Benke G" first="Geza" last="Benke">Geza Benke</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Dept of Epidemiology and Preventive Medicine, Monash University</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kromhout, Hans" sort="Kromhout, Hans" uniqKey="Kromhout H" first="Hans" last="Kromhout">Hans Kromhout</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>12 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Mirabelli, Maria C" sort="Mirabelli, Maria C" uniqKey="Mirabelli M" first="Maria C." last="Mirabelli">Maria C. Mirabelli</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Dept of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine</s1><s2>Winston-Salem, NC</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Winston-Salem, NC</wicri:noRegion></affiliation></author><author><name sortKey="Mehta, Amar J" sort="Mehta, Amar J" uniqKey="Mehta A" first="Amar J." last="Mehta">Amar J. Mehta</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Swiss Tropical and Public Health Institute, Basel; School of Medicine, University of Basel</s1><s2>Basel</s2><s3>CHE</s3><sZ>14 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Dept of Environmental Health, Harvard School of Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Schlunssen, Vivi" sort="Schlunssen, Vivi" uniqKey="Schlunssen V" first="Vivi" last="Schlünssen">Vivi Schlünssen</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Section of Environment, Occupation and Health, Dept of Public Health, Aarhus University</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Sigsgaard, Torben" sort="Sigsgaard, Torben" uniqKey="Sigsgaard T" first="Torben" last="Sigsgaard">Torben Sigsgaard</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Section of Environment, Occupation and Health, Dept of Public Health, Aarhus University</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Blanc, Paul D" sort="Blanc, Paul D" uniqKey="Blanc P" first="Paul D." last="Blanc">Paul D. Blanc</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Division of Occupational and Environmental Medicine, Dept of Medicine, University of California</s1><s2>San Francisco, CA</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>San Francisco, CA</wicri:noRegion></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Centre for Research in Environmental Epidemiology (CREAL)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>18 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Hospital del Mar Medical Research Institute (IMIM)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>18 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>CIBER Epidemiologia y Salud Pública (CIBERESP)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>18 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>National School of Public Health</s1><s2>Athens</s2><s3>GRC</s3><sZ>18 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Anto, Josep M" sort="Anto, Josep M" uniqKey="Anto J" first="Josep M." last="Anto">Josep M. Anto</name></author><author><name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name></author></analytic><series><title level="j" type="main">The European respiratory journal</title><title level="j" type="abbreviated">Eur. respir. j.</title><idno type="ISSN">0903-1936</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The European respiratory journal</title><title level="j" type="abbreviated">Eur. respir. j.</title><idno type="ISSN">0903-1936</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Asthma</term><term>Community health</term><term>European community</term><term>Health status</term><term>Occupational exposure</term><term>Occupational medicine</term><term>Respiratory disease</term><term>Respiratory system</term><term>Respiratory tract</term><term>Survey</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil respiratoire</term><term>Exposition professionnelle</term><term>Médecine du travail</term><term>Adulte</term><term>Asthme</term><term>Communauté européenne</term><term>Santé communautaire</term><term>Appareil respiratoire</term><term>Voie respiratoire</term><term>Etat sanitaire</term><term>Enquête</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine du travail</term><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS). Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect. Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma. These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Bavière</li><li>Catalogne</li><li>District de Haute-Bavière</li><li>East Middle Sweden</li><li>Rhône-Alpes</li><li>Svealand</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Grenoble</li><li>Melbourne</li><li>Munich</li><li>Orsay</li><li>Uppsala</li><li>Utrecht</li></settlement><orgName><li>Université Joseph Fourier</li><li>Université Paris-Sud</li><li>Université d'Uppsala</li><li>Université d'Utrecht</li></orgName></list><tree><noCountry><name sortKey="Anto, Josep M" sort="Anto, Josep M" uniqKey="Anto J" first="Josep M." last="Anto">Josep M. Anto</name><name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name></noCountry><country name="France"><noRegion><name sortKey="Le Moual, Nicole" sort="Le Moual, Nicole" uniqKey="Le Moual N" first="Nicole" last="Le Moual">Nicole Le Moual</name></noRegion><name sortKey="Jacquemin, Benedicte" sort="Jacquemin, Benedicte" uniqKey="Jacquemin B" first="Bénédicte" last="Jacquemin">Bénédicte Jacquemin</name><name sortKey="Jacquemin, Benedicte" sort="Jacquemin, Benedicte" uniqKey="Jacquemin B" first="Bénédicte" last="Jacquemin">Bénédicte Jacquemin</name><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Carsin, Anne Elie" sort="Carsin, Anne Elie" uniqKey="Carsin A" first="Anne-Elie" last="Carsin">Anne-Elie Carsin</name></region><name sortKey="Jacquemin, Benedicte" sort="Jacquemin, Benedicte" uniqKey="Jacquemin B" first="Bénédicte" last="Jacquemin">Bénédicte Jacquemin</name><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><name sortKey="Urrutia, Isabel" sort="Urrutia, Isabel" uniqKey="Urrutia I" first="Isabel" last="Urrutia">Isabel Urrutia</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Radon, Katja" sort="Radon, Katja" uniqKey="Radon K" first="Katja" last="Radon">Katja Radon</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Norback, Dan" sort="Norback, Dan" uniqKey="Norback D" first="Dan" last="Norback">Dan Norback</name></region><name sortKey="Toren, Kjell" sort="Toren, Kjell" uniqKey="Toren K" first="Kjell" last="Toren">Kjell Toren</name></country><country name="Italie"><noRegion><name sortKey="Olivieri, Mario" sort="Olivieri, Mario" uniqKey="Olivieri M" first="Mario" last="Olivieri">Mario Olivieri</name></noRegion><name sortKey="Cazzoletti, Lucia" sort="Cazzoletti, Lucia" uniqKey="Cazzoletti L" first="Lucia" last="Cazzoletti">Lucia Cazzoletti</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Benke, Geza" sort="Benke, Geza" uniqKey="Benke G" first="Geza" last="Benke">Geza Benke</name></region></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Kromhout, Hans" sort="Kromhout, Hans" uniqKey="Kromhout H" first="Hans" last="Kromhout">Hans Kromhout</name></region></country><country name="États-Unis"><noRegion><name sortKey="Mirabelli, Maria C" sort="Mirabelli, Maria C" uniqKey="Mirabelli M" first="Maria C." last="Mirabelli">Maria C. Mirabelli</name></noRegion><name sortKey="Blanc, Paul D" sort="Blanc, Paul D" uniqKey="Blanc P" first="Paul D." last="Blanc">Paul D. Blanc</name><name sortKey="Mehta, Amar J" sort="Mehta, Amar J" uniqKey="Mehta A" first="Amar J." last="Mehta">Amar J. Mehta</name></country><country name="Suisse"><noRegion><name sortKey="Mehta, Amar J" sort="Mehta, Amar J" uniqKey="Mehta A" first="Amar J." last="Mehta">Amar J. Mehta</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Schlunssen, Vivi" sort="Schlunssen, Vivi" uniqKey="Schlunssen V" first="Vivi" last="Schlünssen">Vivi Schlünssen</name></noRegion><name sortKey="Sigsgaard, Torben" sort="Sigsgaard, Torben" uniqKey="Sigsgaard T" first="Torben" last="Sigsgaard">Torben Sigsgaard</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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